What is Eprosartan?
Eprosartan is an angiotensin II receptor antagonist used in the treatment of high blood pressure (hypertension). It works by relaxing blood vessels, thereby lowering blood pressure. Eprosartan was initially developed for this use but has largely been discontinued in favor of other antihypertensive medications such as olmesartan and valsartan. However, it remains available under some brand names and can still be used to treat hypertension when other options are not suitable.
What is Eprosartan used for?
Eprosartan is an angiotensin II receptor antagonist (also known as an ARB) used in the treatment of high blood pressure. It works by blocking the action of angiotensin II, a potent vasoconstrictor that causes blood vessels to constrict and increase blood pressure.
As an ARB, eprosartan blocks the binding of angiotensin II to its receptor on the surface of vascular smooth muscle cells and other tissues. This results in decreased peripheral resistance and increased renal sodium excretion, leading to a decrease in blood pressure. By blocking the renin-angiotensin system (RAS), eprosartan also has anti-proteinuric effects, making it beneficial for patients with kidney disease or diabetic nephropathy.
Eprosartan is usually administered orally once daily and can be used alone or in combination with other antihypertensive agents. It is metabolized primarily by the liver enzyme CYP2C19 to its active carboxylic acid metabolite, which retains full antagonist activity at angiotensin II receptors. The use of eprosartan as an initial treatment for hypertension has been studied in various clinical trials and found to be effective in reducing blood pressure in patients with essential hypertension or those with renal disease.
Eprosartan side effects
• Edema • Headache • Dizziness • Fatigue • Abnormal laboratory tests (elevated liver enzymes, etc.) • Gastrointestinal disturbances • Musculoskeletal pain • Respiratory tract infections • Nausea • Diarrhea • Rash • Pruritus
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