What is Ertugliflozin-metformin?
Ertugliflozin-metformin is a fixed-dose combination medication containing ertugliflozin and metformin. It is used in the treatment of type 2 diabetes mellitus, with ertugliflozin acting as a sodium-glucose cotransporter 2 (SGLT2) inhibitor to reduce glucose reabsorption in the kidneys and increase urine glucose excretion, and metformin as an insulin sensitizer to decrease hepatic glucose production. The combination helps to lower blood sugar levels and improve glycemic control. It is taken orally once daily with a meal or within 60 minutes after a meal, regardless of food intake.
What is Ertugliflozin-metformin used for?
Steglatro, also known as ertugliflozin-metformin, is an oral antidiabetic drug that combines the dipeptidyl peptidase-4 (DPP-4) inhibitor ertugliflozin with the biguanide metformin. This medication is used in adults to improve glycemic control in type 2 diabetes mellitus patients who have failed to achieve adequate control on diet and exercise alone, or as add-on therapy when the disease process is more advanced.
Ertugliflozin is a potent sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor that selectively blocks glucose reabsorption in the kidneys, thereby reducing the amount of glucose present in the urine. Metformin, on the other hand, works by decreasing glucose production in the liver and increasing insulin sensitivity. The combination of these two mechanisms of action allows Steglatro to effectively lower fasting plasma glucose levels and HbA1c values in patients with type 2 diabetes.
Steglatro has been shown to produce significant reductions in HbA1c, with a mean decrease of approximately 1.6-2.3% from baseline, without causing clinically significant weight gain or changes in blood pressure. The overall safety profile of Steglatro is generally well-tolerated, with the most common adverse events being urinary tract infections and increased urination frequency, likely due to its SGLT2 inhibiting properties. However, it’s essential to consider potential contraindications and monitor patients for signs of dehydration or hypotension.
Dosage and Administration
Steglatro is available in two different tablet strengths: 500 mg/250 mg (ertugliflozin-metformin) and 500 mg/500 mg (ertugliflozin-metformin). The recommended starting dose is one 500 mg/250 mg or 500 mg/500 mg tablet once daily, which may be titrated based on individual patient needs. Patients should receive appropriate education regarding proper dosing instructions, as they must not take more than two tablets per day.
Contraindications and Warnings
Steglatro is contraindicated in patients with a history of ketoacidosis or severe hyperglycemia, as well as those who have had pancreatitis associated with diabetes. There may be interactions with other medications that increase the risk of hypoglycemia. Additionally, Steglatro has not been studied in pregnant women, and there is limited experience with its use during lactation.
As always, healthcare providers should consult official prescribing information and reputable sources for comprehensive guidance on the proper use and management of patients on this medication.
Ertugliflozin-metformin side effects
• Diarrhea • Hypoglycemia • Nausea • Abdominal pain • Headache • Dizziness • Fatigue • Muscle weakness • Urinary tract infection • Injection site reactions (for oral tablet form) • Hypersensitivity reactions (rare) • Increased risk of diabetic ketoacidosis • Increased risk of acute kidney injury
Disclaimer
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