What is Erythromycin ethylsuccinate?
Erythromycin ethylsuccinate is an oral form of the macrolide antibiotic erythromycin, designed for pediatric use. It is used to treat various bacterial infections caused by susceptible microorganisms, including strep throat and certain skin and respiratory tract infections. The medication works by inhibiting protein synthesis in bacteria, ultimately killing or preventing their growth. Erythromycin ethylsuccinate is available in a suspension formulation to facilitate oral administration in children.
What is Erythromycin ethylsuccinate used for?
Erythromycin ethylsuccinate, also known as EES, is an oral antibiotic medication that belongs to the class of macrolide antibiotics. It is a derivative of erythromycin, a naturally occurring antibiotic produced by the bacterium Streptomyces erythreus. The addition of ethylsuccinate to erythromycin enhances its solubility and bioavailability in the gastrointestinal tract.
Erythromycin ethylsuccinate is commonly used to treat various bacterial infections caused by susceptible organisms, including respiratory tract infections (such as tonsillitis, pharyngitis, and bronchitis), skin and soft tissue infections, and gastrointestinal infections. The antibiotic works by inhibiting protein synthesis in bacteria, ultimately leading to their death or inhibition of growth. EES is available in oral suspensions and tablets for pediatric use, with a typical dosage form consisting of 125-250 mg erythromycin base per teaspoonful of suspension. Its effectiveness has been demonstrated against a wide range of Gram-positive bacteria, including Streptococcus pyogenes, Staphylococcus aureus, and Haemophilus influenzae.
Key Features
- Antibiotic Class: Macrolide
- Indications: Treatment of bacterial infections caused by susceptible organisms, such as respiratory tract infections, skin and soft tissue infections, and gastrointestinal infections.
- Mechanism of Action: Inhibits protein synthesis in bacteria by binding to the 50S ribosomal subunit.
- Dosage Forms: Oral suspensions (125-250 mg erythromycin base per teaspoonful) and tablets.
Erythromycin ethylsuccinate side effects
• Diarrhea • Stomach cramps • Vaginal yeast infection (in women) • Abdominal pain • Headache • Dizziness • Nausea and vomiting • Fever • Rash • Allergic reactions • Gastrointestinal upset • Increased liver enzymes • Hemolytic anemia
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