What is Evacetrapib?
Evacetrapip is an experimental cholesterol-lowering agent that works by inhibiting the cholesteryl ester transfer protein (CETP). It was being developed as a potential treatment for lowering cardiovascular risk in patients with high cholesterol, but its development was discontinued due to unfavorable results from clinical trials.
What is Evacetrapib used for?
Evacetrapip is an investigational medication that was being developed as a treatment for patients with cardiovascular disease and, more specifically, for those at risk of having another heart attack. It works by inhibiting the cholesteryl ester transfer protein (CETP), which plays a key role in lipid metabolism and is involved in transporting cholesterol from HDL particles to LDL or VLDL particles. By inhibiting CETP, Evacetrapip increases the levels of high-density lipoprotein (HDL) or “good” cholesterol while reducing low-density lipoprotein (LDL) or “bad” cholesterol and triglycerides.
The drug’s development was aimed at preventing major coronary events such as heart attacks. The exact mechanism by which CETP inhibition affects atherosclerosis is still somewhat complex but it appears to be related to an increase in the production of anti-inflammatory cytokines while inhibiting the pro-inflammatory ones, thus reducing plaque formation and progression. However, despite early promise, the development of Evacetrapib was discontinued due to concerns about its efficacy on cardiovascular events in patients at risk.
Evacetrapib side effects
- Headache
- Elevated liver enzymes (ALT, AST)
- Increased blood pressure
- Hypertension
- Abdominal pain
- Nausea
- Vomiting
- Dizziness
- Fatigue
- Muscle weakness
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