What is Evkeeza?
Evkeeza (ezetimibe) is an oral cholesterol-lowering medication used in the management of primary hyperlipidemia, specifically high cholesterol levels. It works by inhibiting the intestinal absorption of dietary cholesterol and certain types of fat. As a monotherapy or as part of combination therapy with statins or other lipid-lowering medications, Evkeeza helps lower low-density lipoprotein (LDL) cholesterol levels in patients who are unable to achieve desired reductions through diet and exercise alone.
What is Evkeeza used for?
Evkeeza, also known as Evinacumab-dgnia, is an injectable medication used in the treatment of adults with high levels of lipoprotein(a) [Lp(a)]. Lp(a) is a type of cholesterol that can accumulate in the bloodstream and contribute to the development of cardiovascular diseases. Evkeeza works by inhibiting the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzyme involved in the regulation of low-density lipoprotein (LDL) cholesterol levels.
By targeting PCSK9, Evkeeza reduces the production of LDL cholesterol and other apoB-containing lipoproteins, leading to a decrease in Lp(a) levels. This reduction can help prevent or delay the progression of cardiovascular diseases, such as heart attacks, strokes, and peripheral artery disease. The safety and efficacy of Evkeeza have been demonstrated in clinical trials, with significant reductions in Lp(a) levels observed across various patient populations.
As a medication, Evkeeza is administered via injection every 4 weeks, typically over 30 minutes. Patients receiving Evkeeza should be monitored regularly for changes in lipid profiles and cardiovascular risk factors. It’s essential to note that Evkeeza may interact with other medications or have adverse effects on the liver or kidneys in some individuals.
References
- FDA-approved label
- Clinical trial data
Evkeeza side effects
• Nausea • Vomiting • Abdominal pain • Headache • Dizziness • Fatigue • Muscle weakness • Back pain • Rash • Itching • Hives • Increased liver enzymes (ALT/AST) • Lipid elevations • Injection site reactions (redness, swelling, or pain at the site of injection)
Disclaimer
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