What is Felodipine-amlodipine?
Felodipine: A calcium channel blocker used in the treatment of hypertension and angina. It works by relaxing blood vessels to improve blood flow and reduce blood pressure.
Amlodipine: Also a calcium channel blocker, it is primarily used for treating high blood pressure and certain types of chest pain. It helps relax blood vessels to improve blood flow and reduce symptoms.}
What is Felodipine-amlodipine used for?
Felodipine-amlodipine, also known as the combination product of felodipine and amlodipine, is an antihypertensive medication used to treat high blood pressure. The drug combines two calcium channel blockers: felodipine, which targets dihydropyridine receptors on smooth muscle cells in blood vessels, causing vasodilation and reducing peripheral resistance; and amlodipine, which blocks voltage-dependent L-type calcium channels on cardiac myocytes, also resulting in vasodilation. By combining these two agents, the product aims to provide enhanced efficacy and a broader therapeutic range for managing hypertension.
The combination of felodipine and amlodipine has been shown to have a synergistic effect, leading to increased vasodilatory activity compared to using either medication alone. This property makes Felodipine-Amlodipine an attractive option for patients with refractory or resistant hypertension who require more potent blood pressure control. By inhibiting the entry of calcium ions into cardiac and vascular smooth muscle cells, felodipine-amlodipine reduces the force and rate of contraction in these tissues, resulting in a decrease in peripheral resistance and consequently lowering systemic blood pressure.
Clinical trials have demonstrated the efficacy and safety of Felodipine-Amlodipine in reducing seated systolic and diastolic blood pressures in hypertensive patients. Adverse effects associated with this medication combination are generally consistent with those observed with individual administration of felodipine or amlodipine, including edema, fatigue, headache, and peripheral edema. Despite its potential benefits, the availability and regulatory status of Felodipine-Amlodipine may vary by country due to differing market approvals.
Felodipine-amlodipine side effects
- Back pain
- Chest discomfort
- Cold symptoms
- Dizziness
- Headache
- Infection
- Joint or muscle cramps
- Lightheadedness
- Nausea
- Skin rash
- Stomach upset
- Taste change
- Tiredness
- Unusual taste sensation
- Upper respiratory tract infection
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