Fenofibric

What is Fenofibric?

Fenofibric acid, also known as fenofibrate, is a medication used to lower cholesterol and triglyceride levels in the blood. It belongs to a class of drugs called fibrates. Fenofibrate works by reducing the production of very-low-density lipoprotein (VLDL) and increasing the clearance of VLDL and LDL from the bloodstream. This helps to reduce the risk of cardiovascular disease in individuals with high cholesterol or triglyceride levels. It is often used in combination with statins for the treatment of hypertriglyceridemia and mixed dyslipidemia, as well as alone for primary prevention of major vascular events.

What is Fenofibric used for?

Drug Summary

Fenofibrate is a medication that belongs to the class of drugs known as fibric acid derivatives, specifically a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It works by activating PPARα receptors in the body, which helps to lower the levels of triglycerides and raise the levels of high-density lipoprotein (HDL) or “good” cholesterol in the blood.

Fenofibrate is primarily used to treat individuals with hypertriglyceridemia, a condition characterized by elevated levels of triglycerides in the blood. It is also prescribed for the treatment of mixed dyslipidemia, which involves abnormally high levels of total cholesterol and/or LDL (“bad”) cholesterol along with elevated triglyceride levels. Additionally, fenofibrate has been used off-label to treat conditions such as hypercholesterolemia, where there are high levels of cholesterol in the blood.

Pharmacological Properties

Fenofibrate is available in various forms, including immediate-release tablets and delayed-release capsules. It is usually administered once daily or twice weekly, depending on the specific formulation and patient requirements. The mechanism of action involves the activation of PPARα receptors, which leads to changes in lipid metabolism that result in decreased triglyceride levels and increased HDL cholesterol levels.

Clinical Use

In clinical practice, fenofibrate has been used to treat a range of conditions related to abnormal lipid profiles. It is often prescribed for patients with high triglyceride levels (>150 mg/dL) who are also experiencing elevated total cholesterol or LDL cholesterol levels. The use of fenofibrate may be part of a comprehensive treatment plan that includes lifestyle modifications, dietary changes, and other medications as necessary.

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Fenofibric side effects

• Abdominal pain • Allergic reactions (rash; hives; itching; difficulty swallowing or breathing) • Arthritis • Changes in appetite • Constipation • Decreased blood sugar levels • Depression • Diarrhea • Dizziness • Eye irritation • Fatigue • Increased risk of infections • Joint pain • Muscle weakness • Nausea • Pain or redness at the injection site • Respiratory problems (cough; shortness of breath) • Stomach discomfort • Swelling in hands and feet • Vision changes


Disclaimer

The content on this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. The information provided here is based on general research and may not apply to individual circumstances. We do not guarantee the accuracy or completeness of any content on this website. Always consult with a healthcare professional before making any changes to your medication or health routine.