Furosemide-hydrochlorothiazide

What is Furosemide-hydrochlorothiazide?

Lasic HCT, also known as Furosemide-hydrochlorothiazide combination, is a fixed-dose combination medication. It consists of furosemide, a loop diuretic that increases urine production to remove excess fluid from the body, and hydrochlorothiazide, a thiazide diuretic that reduces fluid retention in the blood vessels. This combination medication is used to treat high blood pressure (hypertension) and edema associated with conditions such as heart failure or kidney disease.

What is Furosemide-hydrochlorothiazide used for?

Furosemide-Hydrochlorothiazide, commonly referred to as Hydrodiuril, is a diuretic combination medication that combines two active pharmaceutical ingredients: furosemide and hydrochlorothiazide. This prescription-only medication belongs to the classes of loop diuretics (furosemide) and thiazide-like diuretics (hydrochlorothiazide). It is primarily used to treat conditions like edema, swelling caused by excessive fluid accumulation in the body.

Mechanism of Action and Clinical Use

Furosemide-Hydrochlorothiazide exerts its diuretic effects by increasing urine production through various mechanisms. Furosemide acts on the loop of Henle in the kidneys to inhibit sodium, potassium, and chloride reabsorption. This results in a significant increase in water excretion from the body. Hydrochlorothiazide works as a thiazide-like diuretic, which enhances sodium, potassium, and chloride excretion, contributing to increased urine output. By combining these two agents, Furosemide-Hydrochlorothiazide achieves additive effects on fluid loss compared to monotherapy with either agent. This dual mechanism is especially beneficial in the management of hypertension (high blood pressure), certain types of nephrotic syndrome, and fluid overload states due to various medical conditions or surgeries.

Important Information

As a diuretic combination medication, Furosemide-Hydrochlorothiazide has potential side effects such as hypokalemia (potassium deficiency), which may necessitate potassium supplements. Patients should also be informed about the risks of dehydration if excessive amounts of fluid are lost during treatment. Regular monitoring of serum electrolytes and renal function is recommended.

Furosemide-hydrochlorothiazide side effects

• Dizziness • Lightheadedness • Headache • Stomach upset • Diarrhea • Vomiting • Abdominal cramps • Increased urination • Flushing • Itching • Skin rash • Muscle weakness • Changes in hearing or balance • Decreased sodium levels in the blood (hyponatremia) • Decreased potassium levels in the blood (hypokalemia)


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