What is Eplerenone-hydrochlorothiazide?
Eplerenone-Hydrochlorothiazide, also known as Zeagra HCT or Inspra HCT, is a combination medication that contains two main active ingredients: eplerenone and hydrochlorothiazide. Eplerenone belongs to the class of diuretics and mineralocorticoid receptor antagonists, while hydrochlorothiazide is a thiazide-type diuretic. This fixed-dose combination is used to treat high blood pressure (hypertension) in adults, including those with mild to moderate hypertension. The medication works by increasing urine production and reducing fluid buildup in the body, thus lowering blood pressure.
What is Eplerenone-hydrochlorothiazide used for?
Drug Name: Eplerenone-Hydrochlorothiazide (Brand Name: Zenicar, Novartis)
Eplerenone-Hydrochlorothiazide is an oral diuretic medication that combines eplerenone, a potassium-sparing mineralocorticoid receptor antagonist, with hydrochlorothiazide, a thiazide-type diuretic. This fixed-dose combination drug is designed to treat hypertension (high blood pressure) and heart failure in adults. Eplerenone-Hydrochlorothiazide works by blocking the action of aldosterone, a hormone that can contribute to high blood pressure.
Eplerenone-Hydrochlorothiazide exerts its diuretic effect through both potassium-sparing and thiazide-type mechanisms. The eplerenone component blocks the effects of aldosterone on the kidneys, leading to reduced sodium retention and potassium loss. Simultaneously, hydrochlorothiazide increases urine production by inhibiting sodium reabsorption in the distal convoluted tubule, promoting the excretion of water and electrolytes. By lowering blood pressure and enhancing renal function, Eplerenone-Hydrochlorothiazide helps alleviate symptoms and reduce complications associated with hypertension and heart failure.
By combining eplerenone and hydrochlorothiazide in a single tablet, Eplerenone-Hydrochlorothiazide simplifies dosing regimens for patients with these conditions. This fixed-dose combination drug is particularly beneficial for managing moderate to severe hypertension and for patients who require both potassium-sparing and thiazide-type diuretic effects.
Eplerenone-hydrochlorothiazide side effects
- Increased risk of stroke
- Heart failure
- Hyperkalemia (high potassium levels)
- Dehydration
- Dizziness
- Headache
- Fatigue
- Muscle weakness
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Allergic reactions (rash, itching, hives)
- Changes in taste
- Muscle cramps
- Coughing
- Wheezing
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