What is Ertapenem-vaborbactam?
Ertapenem-vaborbactam, also known as Vabomere, is an antibiotic medication. It combines the broad-spectrum beta-lactamase inhibitor vaborbactam with ertapenem, a carbapenem antibiotic. This combination extends the activity of ertapenem against certain beta-lactamase-producing bacteria, allowing for treatment of complicated urinary tract infections and skin infections caused by resistant organisms.
What is Ertapenem-vaborbactam used for?
Ertapenem-vaborbactam is a combination antibiotic product that contains ertapenem, a carbapenem-type beta-lactamase inhibitor, and vaborbactam, a boron-containing beta-lactamase inhibitor. This antimicrobial agent is indicated for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis.
Ertapenem-vaborbactam exerts its antibacterial effect by inhibiting bacterial cell wall synthesis and interfering with the beta-lactamase enzymes that can inactivate many antibiotics. The combination of ertapenem and vaborbactam provides a broad spectrum of antimicrobial activity, effective against a wide range of Gram-positive and Gram-negative bacteria, including those resistant to other antibiotics due to beta-lactamase production.
In clinical trials, Ertapenem-vaborbactam has demonstrated efficacy in treating cUTI and pyelonephritis, with a favorable safety profile. It is administered intravenously every 24 hours for patients with normal renal function. However, the dose should be adjusted in patients with impaired renal function to maintain therapeutic levels of the drug in the blood.
The use of Ertapenem-vaborbactam should be considered when treating patients with cUTI or pyelonephritis who have experienced previous treatment failures or are infected with bacteria resistant to other antibiotics. As with all antibiotics, it is essential to monitor for signs of resistance and adjust therapy accordingly.
Ertapenem-vaborbactam side effects
• Infusion site reactions • Diarrhea • Nausea • Abdominal pain • Constipation • Increased liver enzymes • Decreased white blood cell count (neutropenia) • Decreased platelet count (thrombocytopenia) • Renal failure • Hypersensitivity reaction • Headache • Dizziness • Flushing • Rash • Pruritus • Arthralgia • Myalgia • Fatigue • Insomnia • Anxiety • Confusion
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